Alvarez-Buylla’s team estimated cell numbers using only three to five slices from each postmortem sample. Who is right? Researchers who spoke with Alzforum stood squarely behind Boldrini because she used stereology, a gold standard quantitation method, to estimate numbers of neural progenitors throughout the entire dentate gyrus of postmortem brain. It claims some cells bearing neural progenitor markers are actually glia. In contrast, another paper claims brain neurogenesis fizzles during childhood.It blames waning angiogenesis, not faulty neurogenesis, for lost neuroplasticity in old age.Neural progenitor cells proliferate in human hippocampus throughout adulthood, says a new study.
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